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Jesus et al discovered a new
2024-08-27
Jesus et al. discovered a new series of azaindole as Aurora inhibitors through various modification of GSK1070916 (47). They synthesized series from modification of the GSK1070916 and evaluated for in-vitro Aurora-B/INCENP and Aurora-A/TPX2 inhibition assays. Modified filipin 48 and 49 showed IC50
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Acknowledgments br Introduction Prostate cancer is the first
2024-08-27
Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi
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br Introduction Lipoxygenases LOXs are a heterogeneous famil
2024-08-27
Introduction Lipoxygenases (LOXs) are a heterogeneous family of enzymes that catalyze the peroxidation of polyunsaturated fatty acids (PUFAs). By oxidizing free PUFAs, they were shown to contribute to the generation of various bioactive lipid mediators. However, LOX-mediated oxidation of PUFAs es
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Tumor suppressor ARF regulates the activity of p
2024-08-27
Tumor suppressor ARF regulates the activity of p53 by inhibiting the functions of Mdm2. ARF is induced by hyperproliferative signals emanating from oncogenic Ras, overexpressed c-myc, and from deregulated E2F . ARF prevents p53 degradation and leads to increased p53 function by sequestering Mdm2 to
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In this review we will present the traditional and
2024-08-27
In this review, we will present the traditional and actual strategies to study orphan receptors and identify their ligands. An extensive description of the orphan GPCR field has been published in 2013 by Davenport et al. [22]. Therefore, we will focus on the deorphanizations that were reported since
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br HIF Signaling in AA Therapy Resistance An important
2024-08-26
HIF-α Signaling in AA Therapy Resistance An important result emerging from Phase 3 clinical trials testing AA therapies is improvement of progression-free survival (PFS) that is not accompanied by enhanced overall survival (OS) [26]. This dichotomy has been attributed to mechanisms of acquired re
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br Experimental section br Results
2024-08-26
Experimental section Results and discussion Conclusion Acknowledgement This work was supported by the National Natural Science Foundation of China (Grant Nos. 81401489), the Shanghai Pujiang Program (17PJ1402800) and the Shanghai Sailing Program (Grant No. 14YF1409000). Introduction
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Gallein sale Synaptic scaling up is induced within primary v
2024-08-26
Synaptic scaling up is induced within primary visual Gallein sale (V1) by brief sensory deprivation (Desai et al., 2002; Lambo and Turrigiano, 2013). Several studies have examined the transcriptional changes within extracts of V1 following visual deprivation protocols (Lachance and Chaudhuri, 2004;
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Epidermal growth factor EGF has been shown to
2024-08-26
Epidermal growth factor (EGF) has been shown to increase the 12S-lipoxygenase mRNA level by about two-fold in human epidermoid carcinoma A431 cells [71]. This enzyme was shown to be of the platelet-type and associated with the microsomal fraction of the cells [71], [72]. A requirement for EGF recept
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Glu Gln Asp and Asn the main amino acids presented
2024-08-26
Glu, Gln, Asp, and Asn, the main eg5 presented in the present study, are involved in nitrogen assimilation and transport processes within the plants. Furthermore, they are used to build up reserves during periods of nitrogen availability for subsequent use in growth, defense, and reproductive proce
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Another research group assessed pairs of middle aged years
2024-08-26
Another research group assessed 8503 pairs of middle-aged (GYY 4137 morpholine salt sale the twin exposed to surgery had lower scores on cognitive tests in 49% of the pairs. Twins aged 70 and older who underwent hip and knee arthroplasty scored higher on cognitive tests, even higher than those who h
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In summary we identified a novel MLPH ALK
2024-08-26
In summary, we identified a novel MLPH-ALK fusion in AST with discordant results of ALK IHC. In order not to overlook ALK-rearranged AST with rare fusion partners on IHC screening, a sensitive IHC method is preferable. Introduction Lung cancer remains the leading cause of cancer related deaths w
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Compounds and with potent ALR
2024-08-26
Compounds , and with potent ALR2 inhibitory activity were also tested for their inhibition ability against ALR1, as shown in . They all showed low activity with inhibition percentages no more than 45% at the concentration of 10μM, demonstrating good selectivity for ALR2. To evaluate the antioxida
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The decreased AR mediated response has been attributed
2024-08-26
The decreased βAR-mediated response has been attributed to different mechanisms, including an attenuation of PKA activation, an impaired generation of cyclic AMP, a reduced receptor density, and a less efficient coupling to adenylyl-cyclase [10]. However, currently there is no single molecular or ce
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N,N-Dimethylsphingosine Mitochondria from frozen thawed bull
2024-08-26
Mitochondria from frozen-thawed bull sperm are capable of producing energy using pyruvate and lactate as substrates through oxidative pathways (Beorlegui et al., 1997). Based on the present study, heparin capacitated sperm had a lesser lactate concentration in the incubation medium, supporting the h
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