• The Nile tilapia Oreochromis niloticus

  2021-07-27

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.

• Recently naphthoquinone derivatives have shown promising res

  2021-07-27

  

  Recently, naphthoquinone derivatives have shown promising results as antiparasitic lead compounds [28]. Conjugated hybrid compounds could be an effective path to discovery of new drugs by associating two different pharmacophore groups with different mechanisms of action in a single molecule [29,30],

• A An optimized BEI SEIscore based on the trends emerged

  2021-07-27

  

  (A) An “optimized BEI-SEIscore” based on the trends, emerged from the statistical analysis of several optimization studies in pharmaceutical industry (Abad-Zapatero, 2007, Abad-Zapatero and Blasi, 2011). This type of optimized scores has been used in many previous studies. Ki=1nM at 300° K, compare

• The role of DDR in glomerular injury has

  2021-07-27

  

  The role of DDR1 in glomerular injury has been then further studied by the Chatziantoniou group in experimentally-induced crescentic glomerulonephritis, by injection of alloimmune sheep nephrotoxic serum (NTS) [54]. Glomerulonephritis produced a 17-fold increase of DDR1 expression, predominantly in

• br Materials and methods br

  2021-07-27

  

  Materials and methods Results Discussion The studies reported here provide a more direct link between conformations of the glycine-rich region of DAPK and enzyme activity. As schematically illustrated in Fig. 3, the various conformations of DAPK with bound substrate or product can be consid

• Culture conditions particularly temperature which affect

  2021-07-27

  

  Culture conditions (particularly temperature), which affect the pathogenicity of Y. enterocolitica (Bottone, 1997), may also impact its inhibitory properties against cysteine proteases. However, culturing the bacterial strains at 37 instead of 28 °C did not alter remarkably the inhibitory potential

• Introduction Cytochrome P CYP A is the

  2021-07-26

  

  Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The Efaproxiral Sodium level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxi

• br Experimental section br Results br Discussion In

  2021-07-26

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised CA 074 did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by alt

• br Study design br Results To explore potential differences

  2021-07-26

  

  Study design Results To explore potential differences in the volume the different swabs absorb, the loss of weight of tubes filled with water after soaking the different swabs under defined conditions was determined. This revealed that the different swabs absorbed between approximately 0.07 an

• In contrast to AChE BuChE Table

  2021-07-26

  

  In contrast to AChE, BuChE (Table 2) exhibited a measurable time-dependent inactivation only with Prednisone 2 among the four acetophenones in this study. Values of Ki obtained from steady-state inhibition of BuChE by all four acetophenones were, as noted in the Results, 10- to 200-fold greater (in

• br Conflict of interest br Acknowledgements This

  2021-07-26

  

  Conflict of interest Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. We thank Nissan Chemical Industries, Ltd. for the gift of the sample of fluralaner. Introduction As one of the most common cancers in southern China and southeast Asia, nasopharynge

• Interestingly increased level of both circulating ET and uri

  2021-07-26

  

  Interestingly, increased level of both circulating ET-1 and urinary excretion of ET-1 have been observed in patients treated with nephrotoxic immunosuppressive agents as cyclosporine A and tacrolimus (Slowinski et al., 2002). Other nephrotoxic agents, such as cisplatin, also increase urinary excreti

• br Materials and methods br Results br Discussion In

  2021-07-26

  

  Materials and methods Results Discussion In particular, we showed that pancreatic neuroendocrine tumor Arctigenin recognize cAMP as a stimulatory signal for cell proliferation. Conversely, cAMP was found to have an inhibitory effect on cell proliferation in bronchial carcinoids cells. The

• It has been reported that PGE increases expression of

  2021-07-26

  

  It has been reported that PGE2 increases expression of the survivin mRNA (Baratelli et al. 2005) and promotes the stabilization of the survivin protein in some tumor bupropion hydrochloride mg (Krysan et al. 2003). However, it is unclear whether PGE2 affects the expression of survivin mRNA or promo

• Up to of the host B cells are

  2021-07-26

  

  Up to 10% of the host L-Mimosine are infected with EBV during acute infectious mononucleosis. Most of these cells are effectively cleared by the immune system, but some downregulate viral gene expression and differentiate into safety in the resting memory B cell pool. In the persisting infection, t

14945 records 601/997 page Previous Next First page 上5页 601602603604605 下5页 Last page