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This data is in accordance
2021-10-22
This data is in accordance with our recent results on the influence of cholesterol-depleting agent methyl-β-cyclodextrin on platelets (Borisova et al., 2011a). Dissipation of the proton electrochemical gradient of secretory granules by methyl-β-cyclodextrin did not evoke the release of endogenous gl
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Because of the relationship between
2021-10-22
Because of the relationship between carbohydrate consumption and chronic diseases such as obesity and type II diabetes (Hu, van Dam, & Liu, 2001), there is mounting interest to evaluate the quality of CTPB through analysis by glycemic index (GI) and Englyst assay, for example (Englyst, Kingman, & Cu
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L Family Leguminosae widely distributed in tropical
2021-10-22
L. (Family Leguminosae) widely distributed in tropical and subtropical regions of the world. As a medicinal and edible plant, it is widely used in Asia, especially in China, Korea, Japan and India. It was first recorded in Shen Nong Ben Cao Jing (神农本草经), and was described having the effect of cleari
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In the gastrointestinal GI tract CART expression has been de
2021-10-22
In the gastrointestinal (GI) tract CART expression has been described in the enteric nervous system in rats (Ekblad et al., 2003), pigs (Wierup et al., 2007), sheep (Arciszewski et al., 2009), guinea pigs (Ellis and Mawe, 2003) and humans (Kasacka et al., 2012). Less is known about CART expression i
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Further we examined the degradation of
2021-10-22
Further, we examined the degradation of Cx43. Autophagy and the proteasome system have previously been implicated in Cx43 degradation (Falk et al., 2014). DEX inhibited communication between Nicotinamide by promoting the degradation of Cx43 through autophagy in osteocytes (Gao et al., 2016). In our
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The atomic model of Ce
2021-10-22
The atomic model of Ce-INX6 provides an additional interpretation to the Ce-INX6ΔN mutant structure at low-resolution [41]. Given that the N-terminal residues from 2 to 19 are deleted in the Ce-INX6ΔN mutant, the N-terminal funnel found in the pore of the wild-type Ce-INX6 should be lost in the Ce-I
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Of note the intracellular egg compartment exhibiting SA gal
2021-10-22
Of note, the intracellular egg compartment exhibiting SA-β-gal activity also exhibits lipofuscin auto-fluorescence (Fig. 6B), and it is co-stained with the lipid-specific dye SBB (Supplemental Fig. 5). On the one hand, these findings reflect the fact that the pool of yolk protein contains lipoprotei
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Through the analysis of various synthetic GPR agonists
2021-10-21
Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic Nitecapone motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering T
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br Acknowledgements The authors have
2021-10-21
Acknowledgements The authors have no ethical conflicts to disclose. The authors have no conflicts of interest to declare. This work was funded by the Research Council of Lithuania. Introduction This paper studies whether there is a causal influence of the risk-taking incentives provided by op
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In non Hodgkin lymphoma the catalytic SET
2021-10-21
In non-Hodgkin lymphoma the catalytic SET domain of the histone methyltransferase EZH2 is subject to recurrent heterozygous missense mutations . These alterations have been observed in ∼20% of patients with diffuse large B cell lymphoma (DLBCL) and ∼10% of patients with follicular lymphoma (FL). The
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Enzyme linked immunosorbent assay ELISA is a rapid and
2021-10-21
Enzyme-linked immunosorbent assay (ELISA) is a rapid and simple test widely used for the detection of humoral immune responses following infection/vaccination. However, commercially available ILTV ELISA use the whole virus as the detecting antigen and therefore may not be sensitive for the detection
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To test our refinement protocol we considered
2021-10-21
To test our refinement protocol, we considered a benchmark set of 12 N-linked glycan-containing protein structures determined by X-ray crystallography at resolutions ranging between 1.9 Å and 3.5 Å and comprising a total of 133 glycan units. We identified four incorrect anomeric configurations and 2
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Kern et al observed an overall improvement in behaviors
2021-10-21
Kern et al observed an overall improvement in behaviors typical for autism during TR. They used the Childhood Autism Rating Score (CARS), to determine the intensity of the change and found lower CARS values after 3 (t(21) = 2.73, p UO 126 comparison of differences in QoL improvement in both groups,
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br Introduction The glucagon receptor
2021-10-21
Introduction The glucagon receptor (GCGR) is a G-protein-coupled receptor expressed mainly in the liver and kidney. Upon glucagon binding, it activates the stimulatory G protein (Gs) and increases cAMP level, subsequently transducing glucagon signaling involved in glucose, amino acids and lipid m
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Here we used chemogenetic modulation of MBH GHSR neurons
2021-10-21
Here, we used chemogenetic modulation of MBH GHSR neurons to address the role of the endogenous ghrelin system in the normal, hyperphagic response to a short-term fast. Studies demonstrating the requirement of an intact ghrelin-GHSR system for the rebound food intake following fasting have been inco
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