• Introduction Glaucoma consists of a group of

  2024-04-07

  

  Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion bml definition and damage of the optical nerve. It is well accepted that a criti

• The central problem in amnesia developing following impairme

  2024-04-07

  

  The central problem in amnesia developing following impairment of long-term memory consolidation or reconsolidation is a question of the underlying mechanisms, whether it is caused by impairment of retrieval or memory storage mechanisms [3,8,9,[15], [16], [17], [18]]. To answer this question, severa

• Luciferase Immunoprecipitation Systems LIPS which

  2024-04-03

  

  Luciferase Immunoprecipitation Systems (LIPS), which utilizes recombinant antigens fused to the enzyme reporter Renilla luciferase (Ruc) to detect patient antibodies, provides a unique platform to investigate p38 inhibitor directed against a variety of antigenic targets [25]. Previously, LIPS has b

• Matrix metalloprotease inhibitors are increasingly

  2024-04-03

  

  Matrix metalloprotease inhibitors are increasingly available and tested for other indications in clinical trials. The present study suggests that either ADAM10 or TACE inhibition alone will not maximally restore leukocyte Axl function. We found that lower doses of ADAM10/TACE inhibitors exhibit simi

• Lower LDL C mediated by variants

  2024-04-03

  

  Lower LDL-C mediated by variants in the ACL gene is causally associated with the risk of cardiovascular events. Because, genetic variants that mimic the effect of an ACL inhibitor have the same effect on the risk of cardiovascular events per unit change in LDL-C as variants that mimic the effect of

• Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO) The is

  2024-04-03

  

  The isoelectric point of CL-ARG was determined by native IEF at a Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO) gradient in the range (3–10) using standard protein markers with known isoelectric points. Native IEF reveals the presence of only one major band for CL-ARG with a slightly neutra

• Introduction According to Uganda s Ministry of Health

  2024-04-03

  

  Introduction According to Uganda's Ministry of Health (MOH 2012a:91), intermittent preventive treatment (IPT) to avoid malaria during pregnancy is a free preventive service available to all pregnant women without clinical signs and symptoms of malaria, attending prenatal clinics. However, pregnant

• si cid Due to anatomical and physiologic characteristics of

  2024-04-03

  

  Due to anatomical and physiologic characteristics of the eye, administration of ophthalmic medicines is difficult and many studies showed that only approximately 5% of the administrated dose are absorbed by intraocular tissues, making the treatment unfeasible for diseases located in posterior segmen

• Our surprising results show that AAD treated

  2024-04-03

  

  Our surprising results show that AAD-treated tumors adjacent to adipose tissues and in steatotic liver continue to grow in the presence of a minimal number of microvessels. In non-adipose tumor models, the similar degree of vascular suppression is translated into marked suppression of tumor growth.

• br Introduction Sustained over activation of neurohormonal s

  2024-04-03

  

  Introduction Sustained over-activation of neurohormonal systems is a hallmark in the pathophysiology of cardiac dysfunction following myocardial infarction (MI) and heart failure (HF). Inhibitors of the renin-angiotensin Atractyloside Dipotassium Salt system (RAAS) constitute cornerstones of pha

• Recently the FDA approved the first

  2024-04-03

  

  Recently, the FDA approved the first blood-based test for the detection of EGFR mutations in non-small cell lung cancer patients (http://www.fda.gov) (Voelker, 2016). This allows detection of specific, recurrent mutations, which can help the selection of the patients that could benefit from Erlotini

• Neural activity resulting from sensory experience is require

  2024-04-03

  

  Neural activity resulting from sensory experience is required for the refinement and maturation of neural circuits during cortical critical periods. This refinement is thought to be important for functional optimization of primary sensory cortices, enabling critical functions such as feature detecti

• br Results br Discussion Here we

  2024-04-03

  

  Results Discussion Here, we uncovered a role for Wnt-Fz7 signaling in LTP-dependent spine plasticity and synaptic localization of AMPARs. We demonstrated that LTP induction increased Wnt7a/b protein at GW788388 mg and spines. Direct blockade of endogenous Wnts impaired LTP-mediated structural

• The zebrafish Danio rerio is a

  2024-04-02

  

  The zebrafish (Danio rerio) is a popular model organism for virtually any biological function of vertebrates, and has, therefore, received a wide distribution in particular in developmental biology and toxicology (Strähle et al., 2012). With respect to AChE, the zebrafish has, e.g., been identified

• 1,2-Dilauroyl-sn-glycerol mg Fig A shows a schematic represe

  2024-04-02

  

  Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the

14945 records 170/997 page Previous Next First page 上5页 166167168169170 下5页 Last page